Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma

Abstract Background Glioblastoma is an aggressive cancer that originates from abnormal cell growth in the brain and requires metabolic reprogramming to support tumor growth. Metabolic reprogramming involves the upregulation of various metabolic pathways. Although the activation of specific metabolic...

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Autori principali:	Kenji Miki, Mikako Yagi, Ryusuke Hatae, Ryosuke Otsuji, Takahiro Miyazaki, Katsuhiro Goto, Daiki Setoyama, Yutaka Fujioka, Yuhei Sangatsuda, Daisuke Kuga, Nayuta Higa, Tomoko Takajo, Yonezawa Hajime, Toshiaki Akahane, Akihide Tanimoto, Ryosuke Hanaya, Yuya Kunisaki, Takeshi Uchiumi, Koji Yoshimoto
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-11-01
Serie:	Cancer & Metabolism
Soggetti:	Glioblastoma Glutaminolysis Mitochondria Metabolic changes
Accesso online:	https://doi.org/10.1186/s40170-024-00364-0
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