Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

Fibroblast-like synoviocytes (FLSs) are the major effector cells that lead to rheumatoid arthritis (RA) synovitis and joint destruction. Our previous studies showed that Sonic Hedgehog (SHH) signaling pathway is involved in aberrant activation of RA-FLSs and inhibition of SHH pathway decreases proli...

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Ngā kaituhi matua:	Fang Liu, Xiao Xue Feng, Shang Ling Zhu, Hong Yu Huang, Ying Di Chen, Yun Feng Pan, Rayford R. June, Song Guo Zheng, Jian Lin Huang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2018-12-01
Rangatū:	Frontiers in Immunology
Ngā marau:	arthritis rheumatoid Sonic Hedgehog mitogen-activated protein kinases cell proliferation cell migration
Urunga tuihono:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02847/full
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