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Programmed Cell Death Protein 1 Blockade Reduces Glycogen Synthase Kinase 3β Activity and Tau Hyperphosphorylation in Alzheimer’s Disease Mouse Models

Alzheimer’s disease (AD) is a central nervous system degenerative disease, with no effective treatment to date. Administration of immune checkpoint inhibitors significantly reduces neuronal damage and tau hyperphosphorylation in AD, but the specific mechanism is unclear. Here, we found that programm...

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Principais autores: Yulian Zou, Chen-Ling Gan, Zhiming Xin, Hai-Tao Zhang, Qi Zhang, Tae Ho Lee, Xiaodong Pan, Zhou Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
PD1
PDL1
GSK3β
Aβ
tau hyperphosphorylation
APP/PS1
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2021.769229/full
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