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Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

ABSTRACT Guanine nucleotide exchange factors (GEFs) and their small GTPase substrates constitute a fundamental regulatory system that governs diverse cellular processes, including cytoskeletal dynamics, membrane trafficking, and transcriptional regulation. Since their discovery, GEFs have been recog...

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Principais autores: Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-10-01
coleção:MedComm
Assuntos:
cancer metastasis
guanine nucleotide exchange factors
GEF
microtubule dynamics
neurodegenerative diseases
Rho signaling
Acesso em linha:https://doi.org/10.1002/mco2.70362
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