Structure-Based Virtual Screening of Tumor Necrosis Factor-α Inhibitors by Cheminformatics Approaches and Bio-Molecular Simulation

Tumor necrosis factor-α (TNF-α) is a drug target in rheumatoid arthritis and several other auto-immune disorders. TNF-α binds with TNF receptors (TNFR), located on the surface of several immunological cells to exert its effect. Hence, the use of inhibitors that can hinder the complex formation of TN...

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Autori principali:	Sobia Ahsan Halim, Almas Gul Sikandari, Ajmal Khan, Abdul Wadood, Muhammad Qaiser Fatmi, René Csuk, Ahmed Al-Harrasi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-02-01
Serie:	Biomolecules
Soggetti:	tumor necrosis factor–α descriptor analysis 2D-similarity searching pharmacophore modelling molecular docking absorption
Accesso online:	https://www.mdpi.com/2218-273X/11/2/329
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