In Silico Design, Synthesis, and Evaluation of Novel Enantiopure Isoxazolidines as Promising Dual Inhibitors of α-Amylase and α-Glucosidase

Isoxazolidine derivatives were designed, synthesized, and characterized using different spectroscopic techniques and elemental analysis and then evaluated for their ability to inhibit both α-amylase and α-glucosidase enzymes to treat diabetes. All synthesized derivatives demonstrated a varying range...

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Autors principals:	Fahad Alhawday, Fahad Alminderej, Siwar Ghannay, Bechir Hammami, Abuzar E. A. E. Albadri, Adel Kadri, Kaiss Aouadi
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-01-01
Col·lecció:	Molecules
Matèries:	diabetes mellitus molecular docking α-amylase α-glucosidase isoxazolidine ADMET
Accés en línia:	https://www.mdpi.com/1420-3049/29/2/305
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