Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity

Abstract Macrophages infiltrate solid tumors and either support survival or induce cancer cell death through phagocytosis or cytotoxicity. To uncover regulators of macrophage cytotoxicity towards cancer cells, we perform two co-culture CRISPR screens using CAR-macrophages targeting different tumor a...

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Bibliografiske detaljer

Principais autores:	Tianyi Liu, Meng Zhang, Tatyanah Farsh, Haolong Li, Audrey Kishishita, Abhilash Barpanda, Stanley G. Leung, Jun Zhu, Hyuncheol Jung, Junjie Tony Hua, Xiaolin Zhu, Alexander B. Kim, Young Ah Goo, Minsoo Son, Jaenyeon Kim, Aish Subramanian, Martin Sjöström, Katherine C. Fuh, Jocelyn S. Chapman, Julia Carnevale, Luke A. Gilbert, Aparna Lakkaraju, Peter M. Bruno, David Quigley, Arun P. Wiita, Felix Y. Feng, Carl J. DeSelm
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-07-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-60745-x
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