Glucocorticoid receptor hypersensitivity enhances inflammatory signaling and inhibits cell cycle progression in porcine PBMCs

The consequences of glucocorticoid receptor (GR) hypersensitivity during infection have so far received little attention. We previously discovered that a natural gain-of-function Ala610Val substitution in the porcine GR aggravates response of pigs to lipopolysaccharide (LPS)-induced endotoxemia, whi...

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Prif Awduron:	Zhiwei Li, Frieder Hadlich, Klaus Wimmers, Eduard Murani
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2022-11-01
Cyfres:	Frontiers in Immunology
Pynciau:	glucocorticoid receptor hypersensitivity transcriptome porcine PBMCs lipopolysaccharide inflammatory signaling cell cycle progression
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.976454/full
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