An efficient machine-learning framework for predicting protein post-translational modification sites

Abstract Post-Translational Modifications (PTMs), particularly lysine 2-hydroxyisobutyrylation (Khib), represent critical regulatory mechanisms governing protein structure and function, with mounting evidence underscoring their important implications in cellular metabolism, transcriptional regulatio...

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Auteurs principaux:	Heba M. Elreify, Fathi E. Abd El-Samie, Moawad I. Dessouky, Hanaa Torkey, Said E. El-Khamy, Wafaa A. Shalaby
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-08-01
Collection:	Scientific Reports
Sujets:	Post-translational modification Lysine 2-hydroxyisobutyrylation Machine learning LightGBM Protein language models ESM
Accès en ligne:	https://doi.org/10.1038/s41598-025-13178-x
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