Thorough molecular configuration analysis of noncanonical AAV genomes in AAV vector preparations

The unique palindromic inverted terminal repeats (ITRs) and single-stranded nature of adeno-associated virus (AAV) DNA are major hurdles to current sequencing technologies. Due to these characteristics, sequencing noncanonical AAV genomes present in AAV vector preparations remains challenging. To ad...

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Detalhes bibliográficos

Principais autores:	Junping Zhang, Xiangping Yu, Matthew Chrzanowski, Jiahe Tian, Derek Pouchnik, Ping Guo, Roland W. Herzog, Weidong Xiao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-03-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	adeno-associated virus AAV TMCA-AAVseq noncanonical AAV genomes molecular configuration library construction
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050124000317
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