Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains
<p>Abstract</p> <p>Reverse transcriptases from HIV-1 and MuLV respectively prefer Mg<sup>2+ </sup>and Mn<sup>2+ </sup>for their polymerase activity, with variable fidelity, on both RNA and DNA templates. The function of the RNase H domain with respect to these parameters is not yet understood. To ev...
Guardado en:
| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BMC
2009-10-01
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| Colección: | Virology Journal |
| Acceso en línea: | http://www.virologyj.com/content/6/1/159 |
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