Long-term safety and tolerability of transdermal cannabidiol gel in children and adolescents with Fragile X syndrome (ZYN2-CL-017): an interim analysis of an ongoing open-label extension study

Abstract Background Dysregulated endocannabinoid signaling is involved in Fragile X syndrome (FXS), suggesting a potential role for the endocannabinoid signaling modulator, cannabidiol, in treatment. ZYN002 is a synthetic cannabidiol that has been uniquely formulated as a gel for transdermal deliver...

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Bibliografiske detaljer

Principais autores:	Elizabeth Berry-Kravis, Randi Hagerman, Jonathan Cohen, Dejan Budimirovic, Caroline B. Buchanan, Natalie Silove, Nancy Tich, Anthony Thibodeau, Thomas Dobbins, Terri Sebree, Stephen O’Quinn, David S. Albers, Kristen G. Bzdek, George Nomikos, Kumar Budur
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2025-11-01
Serier:	Journal of Neurodevelopmental Disorders
Fag:	Fragile x syndrome Social avoidance Irritability Endocannabinoid system Transdermal cannabidiol
Online adgang:	https://doi.org/10.1186/s11689-025-09657-x
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