Knockout of c‐Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation

Abstract Epidermal growth factor receptor (EGFR) activity is necessary and sufficient for corneal epithelial homeostasis. However, the addition of exogenous Epidermal Growth Factor (EGF) does not reliably restore the corneal epithelium when wounded. This is likely due to high levels of endogenous EG...

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Hlavní autoři:	Brandon L. M. Crotchett, Brian P. Ceresa
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2021-04-01
Edice:	Pharmacology Research & Perspectives
Témata:	c‐Cbl corneal epithelium EGFR membrane trafficking ubiquitylation
On-line přístup:	https://doi.org/10.1002/prp2.756
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