Genotype-degree of hemolysis correlation in hereditary spherocytosis

Abstract Background Hereditary spherocytosis (HS) is a common inherited hemolytic anemia, caused by mutations in five genes that encode erythrocyte membrane skeleton proteins. The red blood cell (RBC) lifespan could directly reflect the degree of hemolysis. In the present cohort of 23 patients with...

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Главные авторы:	Yimeng Shi, Yuan Li, Xiawan Yang, Xiaoxia Li, Guangxin Peng, Xin Zhao, Xu Liu, Yufei Zhao, Jing Hu, Xiangrong Hu, Baohang Zhang, Kang Zhou, Yang Yang, Youzhen Xiong, Jianping Li, Huihui Fan, Wenrui Yang, Lei Ye, Liping Jing, Li Zhang, Fengkui Zhang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2023-06-01
Серии:	BMC Genomics
Предметы:	Hereditary spherocytosis Red blood cell lifespan Degree of hemolysis Levitt’s carbon monoxide breath test Next-generation sequencing
Online-ссылка:	https://doi.org/10.1186/s12864-023-09364-8
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