Combinatorial Virtual Screening Revealed a Novel Scaffold for TNKS Inhibition to Combat Colorectal Cancer

The abnormal Wnt signaling pathway leads to a high expression of β-catenin, which causes several types of cancer, particularly colorectal cancer (CRC). The inhibition of tankyrase (TNKS) activity can reduce cancer cell growth, invasion, and resistance to treatment by blocking the Wnt signaling pathw...

Description complète

Détails bibliographiques

Auteurs principaux:	Chun-Chun Chang, Sheng-Feng Pan, Min-Huang Wu, Chun-Tse Cheng, Yan-Rui Su, Shinn-Jong Jiang, Hao-Jen Hsu
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-01-01
Collection:	Biomedicines
Sujets:	TNKS inhibitor virtual screening pharmacophore Wnt signaling pathway docking β-catenin
Accès en ligne:	https://www.mdpi.com/2227-9059/10/1/143
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!