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Combinatorial Virtual Screening Revealed a Novel Scaffold for TNKS Inhibition to Combat Colorectal Cancer

The abnormal Wnt signaling pathway leads to a high expression of β-catenin, which causes several types of cancer, particularly colorectal cancer (CRC). The inhibition of tankyrase (TNKS) activity can reduce cancer cell growth, invasion, and resistance to treatment by blocking the Wnt signaling pathw...

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Principais autores: Chun-Chun Chang, Sheng-Feng Pan, Min-Huang Wu, Chun-Tse Cheng, Yan-Rui Su, Shinn-Jong Jiang, Hao-Jen Hsu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-01-01
Serier:Biomedicines
Fag:
TNKS inhibitor
virtual screening
pharmacophore
Wnt signaling pathway
docking
β-catenin
Online adgang:https://www.mdpi.com/2227-9059/10/1/143
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