Improved haplotype resolution of highly duplicated MHC genes in a long-read genome assembly using MiSeq amplicons

Long-read sequencing offers a great improvement in the assembly of complex genomic regions, such as the major histocompatibility complex (MHC) region, which can contain both tandemly duplicated MHC genes (paralogs) and high repeat content. The MHC genes have expanded in passerine birds, resulting in...

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Principais autores:	Samantha Mellinger, Martin Stervander, Max Lundberg, Anna Drews, Helena Westerdahl
Format:	Artigo
Jezik:	Inglês
Izdano:	PeerJ Inc. 2023-07-01
Serija:	PeerJ
Teme:	Haploid genome assembly Amplicon sequencing Major histocompatibility complex MHC diversity Family Linkage analysis
Online dostop:	https://peerj.com/articles/15480.pdf
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