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Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activating signals lead to the membrane recruitment...

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Principais autores: Jeffrey S Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G Pelton, David E Wemmer, Jeroen P Roose, John Kuriyan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2013-07-01
coleção:eLife
Assuntos:
cell signaling
nucleotide exchange factor
diacylglycerol
Acesso em linha:https://elifesciences.org/articles/00813
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