Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...

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Главные авторы:	Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
Формат:	Artigo
Язык:	Inglês
Опубликовано:	The Company of Biologists 2021-02-01
Серии:	Disease Models & Mechanisms
Предметы:	trachea tracheomalacia cartilage hedgehog
Online-ссылка:	http://dmm.biologists.org/content/14/2/dmm046573
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