Network pharmacology, prognostic analysis and experimental validation elucidate the therapeutic mechanism of Dingxiang Guanshitong in esophageal cancer

Abstract This study aimed to investigate the target genes of active components in Dingxiang Guanshitong (DGST) and evaluate their significance in the prognosis of esophageal cancer (EC) through integrated approaches, including network pharmacology, molecular docking, prognostic analysis, and in vitr...

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Hlavní autoři:	Hao Zhang, Shi-qi Wang, Xiao-qi Chen, Li-qi Li, Yu-hong Zheng, Ya-ling Zhang, Xue-wen Diao, Pei-yu Yan, Yu-ling Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-05-01
Edice:	Scientific Reports
Témata:	Dingxiang guanshitong Prognostic target genes Esophageal cancer Network pharmacology Molecular docking Pathway enrichment
On-line přístup:	https://doi.org/10.1038/s41598-025-00910-w
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