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Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α

IntroductionWe evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic factors (PPF) of pharmacokinetic (PK) origin impacting immune response (formation of antidrug antibodies) and disease control of inflammatory...

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Hoofdauteurs: Elizabeth A. Spencer, Marla C. Dubinsky, Michael A. Kamm, Maria Chaparro, Paolo Gionchetti, Fernando Rizzello, Javier P. Gisbert, Emily K. Wright, Julien D. Schulberg, Amy L. Hamilton, Dermot P. B. McGovern, Thierry Dervieux
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2024-01-01
Reeks:Frontiers in Immunology
Onderwerpen:
drug response
tumor necrosis factor
clearance
inflammatory bowel disease
pharmacogenetic
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342477/full
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