Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α

IntroductionWe evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic factors (PPF) of pharmacokinetic (PK) origin impacting immune response (formation of antidrug antibodies) and disease control of inflammatory...

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Главные авторы:	Elizabeth A. Spencer, Marla C. Dubinsky, Michael A. Kamm, Maria Chaparro, Paolo Gionchetti, Fernando Rizzello, Javier P. Gisbert, Emily K. Wright, Julien D. Schulberg, Amy L. Hamilton, Dermot P. B. McGovern, Thierry Dervieux
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2024-01-01
Серии:	Frontiers in Immunology
Предметы:	drug response tumor necrosis factor clearance inflammatory bowel disease pharmacogenetic
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342477/full
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