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CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability

Abstract Background The treatment of oral squamous cell carcinoma (OSCC) remains challenging and survival rates have not been improved significantly over the past decades. Integrins have been recognized driving the cancer progression and high expression levels cause poor outcomes in patients afflict...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Maximilian Geyer, Fabian Geyer, Ute Reuning, Sarah Klapproth, Klaus-Dietrich Wolff, Markus Nieberler
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-06-01
Schriftenreihe:Head & Face Medicine
Schlagworte:
Oral squamous cell carcinoma
Integrin beta 6
CRISPR/Cas9
Knock out
Online-Zugang:https://doi.org/10.1186/s13005-024-00437-x
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