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Characterizing the MRI signature of hippocampal sclerosis of aging

Abstract Background Hippocampal sclerosis of aging (HS-A), a common cause of dementia, can currently only be diagnosed at autopsy. We aimed to identify and evaluate MRI metrics to distinguish HS-A from Alzheimer’s Disease neuropathologic change (ADNC) and cases with limited/no pathology. Methods HS-...

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Autori principali: Gustaf Rådman, Amanda E. Denning, Sadhana Ravikumar, Nicola Spotorno, Ranjit Ittyerah, Lisa M. Levorse, John L. Robinson, Theresa Schuck, Sydney A. Lim, Eunice Chung, Madigan Bedard, Winifred Trotman, Alejandra Bahena, María del Mar Arroyo-Jiménez, Alicia Vela, Esther Buendia, Maria Mercedes Iñiguez de Onzoño Martin, María Pilar Marcos Rabal, Mónica Muñoz-López, Rosanna K. Olsen, John A. Detre, Edward B. Lee, David A. Wolk, Daniel T. Ohm, Corey T. McMillan, Ricardo Insausti, David J. Irwin, Paul A. Yushkevich, Laura E. M. Wisse, the Alzheimer’s Disease Neuroimaging Initiative
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-06-01
Serie:Alzheimer’s Research & Therapy
Soggetti:
Hippocampal sclerosis of aging
Magnetic resonance imaging
Neurodegenerative disease
Alzheimer’s Disease neuropathologic change
Dementia
Accesso online:https://doi.org/10.1186/s13195-026-02118-0
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