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Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study

Abstract TDP-43 pathology frequently co-occurs with Alzheimer’s disease (AD), indicative of Limbic-predominant Age-related TDP-43 Encephalopathy neuropathologic changes (LATE-NC), which is associated with more severe medial temporal lobe (MTL) atrophy and cognitive decline compared to ‘pure’ AD. As...

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Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yasmine Salman, Julia Goloubeva, Lara Huyghe, Lisa Quenon, Sandra O. Tomé, Bernard Hanseeuw, Alzheimer’s Disease Neuroimaging Initiative
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-12-01
Rangatū:Acta Neuropathologica Communications
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s40478-025-02200-y
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