Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron.

Mechanical forces are known to induce increases of [Ca(2+)](i) in the aldosterone-sensitive distal nephron (ASDN) cells to regulate epithelial transport. At the same time, mechanical stress stimulates ATP release from ASDN cells. In this study, we combined ratiometric Fura-2 based monitoring of [Ca(...

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Библиографические подробности

Главные авторы:	Mykola Mamenko, Oleg Zaika, Min Jin, Roger G O'Neil, Oleh Pochynyuk
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2011-01-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC3151261?pdf=render
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