Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees.

The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector cell responses may have been a key mechanism of the...

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Principais autores:	Ickwon Choi, Amy W Chung, Todd J Suscovich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Robert J O'Connell, Donald Francis, Merlin L Robb, Nelson L Michael, Jerome H Kim, Galit Alter, Margaret E Ackerman, Chris Bailey-Kellogg
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2015-04-01
叢編:	PLoS Computational Biology
在線閱讀:	http://europepmc.org/articles/PMC4395155?pdf=render
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