Discovery of small molecules against porcine reproductive and respiratory syndrome virus replication by targeting NendoU activity

ABSTRACT Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to animal health and causes substantial economic losses worldwide. The nonstructural protein 11 (NSP11) of the causative agent, PRRS virus (PRRSV), contains a highly conserved nidoviral uridylate-specific endoribonu...

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Hauptverfasser:	Jiaqi Zhu, Yunqiang Lai, Mengqi Cheng, Radha Charan Dash, Shuangshuang Guo, Jintong Guo, Yue Su, Andrew Wolek, Brianna Issacs, Zhenming Liu, Qi Li, Neha Mishra, Antonio Garmendia, M. Kyle Hadden, X. Cindy Tian, Xin He, Young Tang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2025-02-01
Schriftenreihe:	Journal of Virology
Schlagworte:	PRRSV NendoU nidovirus antiviral agents
Online-Zugang:	https://journals.asm.org/doi/10.1128/jvi.02034-24
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