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ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres

Break-induced replication is a specific type of DNA repair that has a co-opted role in telomere extension by telomerase-negative cancer cells. This Alternative Lengthening of Telomeres (or ‘ALT’) is required for viability in approximately 10% of all carcinomas, but up to 50% of the soft-tissue deriv...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Julienne J O’Rourke, Rohan Bythell-Douglas, Elyse A Dunn, Andrew J Deans
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2019-01-01
Schriftenreihe:Nucleus
Schlagworte:
telomeres
dna repair
fanconi anemia
chemotherapy
break-induced replication
precision medicine
synthetic lethal
Online-Zugang:http://dx.doi.org/10.1080/19491034.2019.1685246
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