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Hydrogen Bonds with Fluorine in Ligand–Protein Complexes-the PDB Analysis and Energy Calculations

Fluorine is a common substituent in medicinal chemistry and is found in up to 50% of the most profitable drugs. In this study, a statistical analysis of the nature, geometry, and frequency of hydrogen bonds (HBs) formed between the aromatic and aliphatic C–F groups of small molecules and biological...

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Bibliografiske detaljer
Principais autores: Wojciech Pietruś, Rafał Kafel, Andrzej J. Bojarski, Rafał Kurczab
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-02-01
Serier:Molecules
Fag:
Online adgang:https://www.mdpi.com/1420-3049/27/3/1005
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