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Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa

Tvrm4 mice, a model of autosomal dominant retinitis pigmentosa (RP), carry a mutation of Rhodopsin gene that can be activated by brief exposure to very intense light. Here, we test the possibility of an anatomical, metabolic, and functional recovery by delivering to degenerating Tvrm4 animals, Myrio...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ilaria Piano, Vanessa D’Antongiovanni, Elena Novelli, Martina Biagioni, Michele Dei Cas, Rita Clara Paroni, Riccardo Ghidoni, Enrica Strettoi, Claudia Gargini
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-05-01
Schriftenreihe:Frontiers in Neuroscience
Schlagworte:
retinitis pigmentosa
photoreceptor rescue
oxidative stress
Myriocin
mutation-independent approach
Online-Zugang:https://www.frontiersin.org/article/10.3389/fnins.2020.00372/full
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