Impaired Behavioural Pain Responses in Mice with Inherited Deficiency in GTP Cyclohydrolase 1 in Models of Inflammatory Pain

Background GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been implicated in the development and maintenance of inflammatory pain in rats. In humans, homozygous carriers of a “pain-protective” (PP) haplotype of th...

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Autors principals:	Arafat Nasser, Ole J Bjerrum, Anne-Marie Heegaard, Anette T Møller, Maj Britt Larsen, Louise S Dalbøge, Erik Dupont, Troels S Jensen, Lisbeth B Møller
Format:	Artigo
Idioma:	Inglês
Publicat:	SAGE Publishing 2013-02-01
Col·lecció:	Molecular Pain
Accés en línia:	https://doi.org/10.1186/1744-8069-9-5
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