Impaired Behavioural Pain Responses in Mice with Inherited Deficiency in GTP Cyclohydrolase 1 in Models of Inflammatory Pain
Background GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been implicated in the development and maintenance of inflammatory pain in rats. In humans, homozygous carriers of a “pain-protective” (PP) haplotype of th...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
SAGE Publishing
2013-02-01
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| Seria: | Molecular Pain |
| Dostęp online: | https://doi.org/10.1186/1744-8069-9-5 |
| Etykiety: |
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