The Glucose-Glutamine Metabolic Interplay in MCF-7 Cells, a Hormone-Sensitive Breast Cancer Model

Background: Selective deprivation of glutamine has been shown to accelerate the generation of reactive oxygen species (ROS) and to impair the activity of a specific pentose phosphate pathway (PPP) located within the endoplasmic reticulum (ER). The consequent oxidative damage suggests that glucose fl...

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Autori principali:	Sonia Carta, Maddalena Ghelardoni, Francesca Vitale, Silvia Ravera, Vanessa Cossu, Nadia Bertola, Serena Losacco, Jonathan Martinelli, Edoardo Dighero, Mattia Riondato, Anna Maria Orengo, Matteo Bauckneht, Sabrina Chiesa, Gianmario Sambuceti, Cecilia Marini
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	IMR Press 2024-07-01
Serie:	Frontiers in Bioscience-Landmark
Soggetti:	hormone-sensitive breast cancer glucose and glutamine metabolism cytosolic/reticular pentose phosphate pathway nadph redox status hexose-6-phosphate-dehydrogenase glucose-6-phosphate dehydrogenase
Accesso online:	https://www.imrpress.com/journal/FBL/29/7/10.31083/j.fbl2907251
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