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Dynamics of mutant BCR-ABL-positive clones after cessation of tyrosine kinase inhibitor therapy

Background Point mutations of the BCR-ABL tyrosine kinase domain are considered the predominant cause of imatinib resistance in chronic myeloid leukemia. The expansion of mutant BCR-ABL-positive clones under selective pressure of tyrosine kinase inhibition is referred to as clonal selection; there a...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Benjamin Hanfstein, Martin C. Müller, Sebastian Kreil, Thomas Ernst, Thomas Schenk, Christian Lorentz, Uwe Schwindel, Armin Leitner, Rüdiger Hehlmann, Andreas Hochhaus
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Ferrata Storti Foundation 2011-03-01
Rangatū:Haematologica
Urunga tuihono:https://haematologica.org/article/view/5897
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