Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting Haloperidol Exposure in Healthy and Disease Populations

The physiologically based pharmacokinetic (PBPK) approach can be used to develop mathematical models for predicting the absorption, distribution, metabolism, and elimination (ADME) of administered drugs in virtual human populations. Haloperidol is a typical antipsychotic drug with a narrow therapeut...

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Váldodahkkit:	Mohammed S. Alasmari, Fawaz Alasmari, Abdullah F. Alasmari, Aws Alshamsan, Sary Alsanea, Muhammad F. Rasool, Faleh Alqahtani
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2022-08-01
Ráidu:	Pharmaceutics
Fáttát:	PBPK PK-Sim<sup>®</sup> haloperidol psychosis personalized medicine
Liŋkkat:	https://www.mdpi.com/1999-4923/14/9/1795
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