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Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors

Abstract Chimeric antigen receptor (CAR)‐T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR‐T cells become out of artificial control, and fierce response to CAR‐T therapy may cause severe adverse events, represented by cytokine‐...

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Autori principali: Xinyue Wang, Fanyan Meng, Xiang Li, Luxin Xue, Anni Chen, Yuling Qiu, Zhifan Zhang, Lin Li, Fengcen Liu, Yishan Li, Zhichen Sun, Yanhong Chu, Ruihan Xu, Lixia Yu, Jie Shao, Manman Tian, Xiaoping Qian, Qin Liu, Baorui Liu, Rutian Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2023-04-01
Serie:Advanced Science
Soggetti:
cancer immunotherapy
cytokine‐release syndrome
nanoparticles
on‐target/off‐tumor effects
chimeric antigen receptor‐T (CAR‐T)
Accesso online:https://doi.org/10.1002/advs.202205044
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