Efavirenz metabolism and CNS toxicity in Ugandan children: impact of CYP2B6 genotype and plasma metabolite profiles

IntroductionThe non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is used in antiretroviral therapy (ART) against HIV. EFV is mainly metabolized by CYP2B6 to 8-hydroxyefavirenz (8-OH-EFV) and to a lesser extent by CYP2A6 to 7-hydroxyefavirenz (7-OH-EFV). Previous studies have only exami...

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Hauptverfasser:	Sandra Soeria-Atmadja, Madeleine Pettersson Bergstrand, Pauline Amuge, Sarah Nanzigu, Dickson Bbuye, Johanna Rubin, Adeodata Kekitiinwa, Celestino Obua, Marja-Liisa Dahl, Anton Pohanka, Lars L. Gustafsson, Lars Navér, Jaran Eriksen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-04-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	7-hydroxyefavirenz 8-hydroxy-efavirenz adverse events children efavirenz HIV
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1778383/full
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