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Involvement of H2A variants in DNA damage response of zygotes

Abstract Phosphorylated H2AX, known as γH2AX, forms in response to genotoxic insults in somatic cells. Despite the high abundance of H2AX in zygotes, the level of irradiation-induced γH2AX is low at this stage. Another H2A variant, TH2A, is present at a high level in zygotes and can also be phosphor...

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Hlavní autoři: Yuan Wang, Dai Tsukioka, Shoji Oda, Masataka G. Suzuki, Yutaka Suzuki, Hiroshi Mitani, Fugaku Aoki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2024-05-01
Edice:Cell Death Discovery
On-line přístup:https://doi.org/10.1038/s41420-024-01999-0
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