Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell. Here we report the identification of 20 small-molecule inhibitors t...

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Principais autores:	Anja Kolarič, Marko Jukič, Urban Bren
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-01-01
Colecção:	Pharmaceuticals
Assuntos:	neuropilin 1 SARS-CoV-2 COVID-19 spike binding inhibitors virtual screening small-molecule antagonists
Acesso em linha:	https://www.mdpi.com/1424-8247/15/2/165
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