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Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell. Here we report the identification of 20 small-molecule inhibitors t...

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Principais autores: Anja Kolarič, Marko Jukič, Urban Bren
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-01-01
Serier:Pharmaceuticals
Fag:
neuropilin 1
SARS-CoV-2
COVID-19
spike binding inhibitors
virtual screening
small-molecule antagonists
Online adgang:https://www.mdpi.com/1424-8247/15/2/165
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