CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. Its reduced levels in diet-induced obesity (DIO) contribute to hyperleptinemia and leptin resistance, effects that are regulated by the endocannabinoid (eCB)/CB1R system. Here we...

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Autors principals:	Adi Drori, Asaad Gammal, Shahar Azar, Liad Hinden, Rivka Hadar, Daniel Wesley, Alina Nemirovski, Gergő Szanda, Maayan Salton, Boaz Tirosh, Joseph Tam
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2020-11-01
Col·lecció:	eLife
Matèries:	endocannabinoids leptin resistance ER stress obesity cb1 receptor CHOP
Accés en línia:	https://elifesciences.org/articles/60771
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