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CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. Its reduced levels in diet-induced obesity (DIO) contribute to hyperleptinemia and leptin resistance, effects that are regulated by the endocannabinoid (eCB)/CB1R system. Here we...

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Principais autores: Adi Drori, Asaad Gammal, Shahar Azar, Liad Hinden, Rivka Hadar, Daniel Wesley, Alina Nemirovski, Gergő Szanda, Maayan Salton, Boaz Tirosh, Joseph Tam
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Assuntos:
endocannabinoids
leptin resistance
ER stress
obesity
cb1 receptor
CHOP
Acceso en liña:https://elifesciences.org/articles/60771
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