Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells

Abstract Background Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, and apoptosis plays a key role in its pathogenesis. Distal‐less homeobox 5 (Dlx5) has been reported to induce cell apoptosis. Melatonin, as a powerful antiapoptotic agent, has been widely reported. Aim...

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Principais autores:	Kuibo Zhang, Hua Wang, Ling Mo, Xiaohui Huang, Chao Yuan, Caijun Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-12-01
coleção:	JOR Spine
Assuntos:	apoptosis DLX5 intervertebral disc degeneration melatonin nucleus pulposus cell
Acesso em linha:	https://doi.org/10.1002/jsp2.70014
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