Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior

Understanding drug-surfactant interactions is crucial for optimizing pharmaceutical formulations. This study aimed to comprehensively investigate the physicochemical interactions between phenobarbital sodium (PS) and two anionic bile salts, sodium cholate (NaC) and sodium deoxycholate (NaDC), in aqu...

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Autors principals:	Haytham Abuissa, Ashraf EL-Hashani
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-07-01
Col·lecció:	Next Materials
Matèries:	Bile salts Critical Micelle Concentration (CMC) Interfacial parameters Binding constant Partition coefficient
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2949822825003922
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