Optimised dissociation and multimodal profiling of prostate cancer stroma reveal fibromuscular cell heterogeneity with clinical correlates

BackgroundDynamic remodelling of the tumour microenvironment (TME) plays a central role in prostate cancer (PCa) progression, immune evasion and therapy resistance. However, the co-existence of both tumour-promoting and tumour-restraining stromal elements necessitates extensive characterisation of t...

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Ngā kaituhi matua:	Elisabeth Damisch, Elena Brunner, Lukas Nommensen, Lucy Neumann, Georgios Fotakis, Zlatko Trajanoski, Sieghart Sopper, Georg Schäfer, Martin Puhr, Isabel Heidegger, Marianna Kruithof-de Julio, Natalie Sampson
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2025-11-01
Rangatū:	Frontiers in Cell and Developmental Biology
Ngā marau:	cancer-associated fibroblast prostate cancer smooth muscle cell tissue dissociation single cell RNA sequencing tumour microenvironment
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1653780/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!