γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors

GABA-A receptors (GABAARs) are pentameric ligand-gated ion channels that are assembled mainly from α (α1–6), β (β1–3) and γ (γ1–3) subunits. Although GABAARs containing γ2L subunits mediate most of the inhibitory neurotransmission in the brain, significant expression of γ1 subunits is seen in the am...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Christine L. Dixon, Pankaj Sah, Angelo Keramidas, Joseph W. Lynch, Nela Durisic
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2017-06-01
Schriftenreihe:	Frontiers in Molecular Neuroscience
Schlagworte:	γ1-subunit clustering inhibitory neurotransmission synapse spillover IPSC artificial synapse
Online-Zugang:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00178/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!