Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy
Epilepsy is a spectrum of neurological disorders with many causal factors. The GABA type-A receptor (GABAAR) is a major genetic target for heritable human epilepsies. Here we examine the functional effects of three epilepsy-causing mutations to the α1 subunit (α1T10’I, α1D192N and α1A295D) on inhibi...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2017-12-01
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| Col·lecció: | Neurobiology of Disease |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S0969996117302012 |
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