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Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology

The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compr...

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Principais autores: Srikanth Meka Venkata, Ee Li Chew, Sheshala Ravi
Format: Artigo
Sprog:Inglês
Udgivet: Sciendo 2016-03-01
Serier:Acta Pharmaceutica
Fag:
theophylline
gastroretentive
floating
central composite
peo n12k
Online adgang:https://doi.org/10.1515/acph-2016-0002
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