A multiparametric screen uncovers FDA-approved small molecules that potentiate the nuclear mechano-dysfunctions in ATR-defective cells

Abstract Targeting nuclear mechanics is emerging as a promising therapeutic strategy for sensitizing cancer cells to immunotherapy. Inhibition of the mechano-sensory kinase ATR leads to mechanical vulnerability of cancer cells, causing nuclear envelope softness and collapse and activation of the cGA...

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Hlavní autoři:	Maria Rosaria Cera, Giulia Bastianello, Divya Purushothaman, Adrian Andronache, Flora Ascione, Michela Robusto, Giovanni Fagà, Maurizio Pasi, Giuseppe Meroni, Qingsen Li, Ramveer Choudhary, Mario Varasi, Marco Foiani, Ciro Mercurio
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-12-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-024-80837-w
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